Faculté de Pharmacie de Lille
3, rue du Professeur Laguesse
BP83 - 59006 - Lille Cedex
Tél. : +33 (0)3 20 96 40 40
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INSERM U1008 – Médicaments et Biomatériaux à Libération Contrôlée

   Siteweb du laboratoire : http://u1008.univ-lille2.fr

Equipe U1008

    Liste enseignants de la Faculté de pharmacie dans l’unité/équipe d’accueil :

Pr. Juergen SIEPMANN (Responsable)
Pr. Elisabeth DELCOURT-DEBRUYNE
Pr. Marie-Pierre FLAMENT
Pr. Joel FERRI
Pr. Stéphan HAULON
Dr. Nicolas BLANCHEMAIN
Dr. François BOSCHIN
Dr. Youness KARROUT
Dr. Susanne MUSCHERT
Dr. Florence SIEPMANN
Dr. Mounira HAMOUDI

  Personne à contacter pour faire un stage au laboratoire
Florence SIEPMANN
INSERM U1008
Faculté de Pharmacie
3, rue du Professeur Laguesse - 59006 Lille
Tel : 03.20.96.49.75 - Fax : 03.20.96.49.42

 

  Thématique de l’Inserm U1008 – Médicaments et Biomatériaux à Libération Contrôlée


Principaux Thèmes de recherche

 Controlled Drug Delivery Systems and Biomaterials: Mechanisms and Optimization

 

Mots clés

 Controlled drug delivery, drug release mechanisms, tablets, coated pellets, in-situ forming implants for periodontitis treatment, cochlear implants, drug-eluting stents, bone substitutes

 

Savoir Faire et compétences

 - Manufacturing of controlled drug delivery systems and biomaterials

- Physicochemical and biological characterization in vitro

- Determination of the pharmacokinetics & pharmacodynamics in vivo (animals and clinical trials)

- Elucidation of the underlying mass transport mechanisms

- Mathematical modeling, predictions of the impact of device design parameters

 

10 publications majeures (5 dernières années)

 

Gasmi, H; Danede, F; Siepmann, J; Siepmann, F. Does PLGA microparticle swelling control drug release? New insight based on single particle swelling studies. Journal of Controlled Release 213, 120-127, 2015.

 

Karrout, Y; Dubuquoy, L; Piveteau, C; Siepmann, F; Moussa, E; Wils, D; Beghyn, T; Neut, C; Flament, MP; Guerin-Deremaux, L; Dubreuil, L; Deprez, B; Desreumaux, P; Siepmann, J. In vivo efficacy of microbiota-sensitive coatings for colon targeting: A promising tool for IBD therapy. Journal of Controlled Release 197, 121-130, 2015.

 

Velghe, C; Rosiaux, Y; Marchaud, D; Siepmann, J; Siepmann, F. In-silico simulation of niacin release from lipid tablets: Theoretical predictions and independent experiments. Journal of Controlled Release 175, 63-71, 2014.

 

Amr, G; Sobocinski, J; Koussa, M; El Arid, JM; Nicolini, P; Haulon, S. Staged procedure to prevent major adverse events in extensive aortic aneurysm repair. Journal of Vascular Surgery 57, 1671-1673, 2013.

 

Rosiaux, Y; Muschert, S; Chokshi, R; Leclercq, B; Siepmann, F; Siepmann, J. Ethanol-resistant polymeric film coatings for controlled drug delivery. Journal of Controlled Release 169, 1-9, 2013.

 

Couchet, G; Maurel, B; Sobocinski, J; Hertault, A; Le Roux, M; Azzaoui, R; Haulon, S. An optimal combination for EVAR: Low profile endograft body and continuous spiral stent limbs. European Journal of Vascular and Endovascular Surgery 46, 29-33, 2013.

 

Krenzlin, S; Vincent, C; Munzke, L, Gnansia, D; Siepmann, J; Siepmann, F. Predictability of drug release from cochlear implants. Journal of Controlled Release 159, 60-68, 2012.

 

Kreye, F; Hamm, G; Karrout, Y; Legouffe, R; Bonnel, D; Siepmann, F; Siepmann, J. MALDI-TOF MS Imaging of controlled release implants. Journal of Controlled Release 161, 98-108, 2012.

 

Siepmann, J; Siepmann, F. Modeling of diffusion controlled drug delivery. Journal of Controlled Release 161, 351-362, 2012.

 

Siepmann, F; Eckart, K; Maschke, A; Kolter, K; Siepmann, J. Modeling drug release from PVAc/PVP matrix tablets. Journal of Controlled Release 141, 216-222, 2010.

 

Brevet (s)

 

Haeusler, O; Degrave, M.H.; Wils, D; Krenzlin, S; Siepmann, J.

Modified starch derivative-based matrix for colon targeting.

EP 2 446 877 A1

Date of publication: 02 May 2012

 

Siepmann, J; Karrout, Y; Guerin-Deremaux, L; Klaeyle, J; Wils, D.

Indigestible polymer: starch acetate -based film coatings for colon targeting.

WO/2011/135055

Date of publication: 3 November 2011

 

Siepmann, J; Cuppok, Y.

Controlled release solid dose forms.

US 2012/0328697 A1

Date of publication: 27 December 2012

 

Siepmann, J; Chokshi, R; Sestrick, M; Velghe, C.

Controlled release solid dose forms.

WO 2014055740 A1

Date of publication: 10 April 2014

 

Collaborations académiques 

 

National

 

Prof. D. Bourissou

CNRS UMR 5069, Toulouse

 

Prof. Dr. Amélie Bochot and Prof. Dr. Florence Agnely

CNRS UMR 8207, Paris-Sud

 

Prof. Dr. Evelyne Ferrari

INSERM U 1159, Paris

 

Prof. Dr. Tennenbaum and Prof. Dr. Davideau

INSERM, Strasbourg

 

European

 

Prof. Dr. R. Bodmeier

Freie Universitaet Berlin, Berlin, Germany

 

Prof. Dr. G. Winter

Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany

 

Prof. Dr. R. Remon and Prof. Dr. C. Vervaet

University of Ghent, Gent, Belgium

 

Prof. Dr. K. Amighi

Free University of Brussels, Brussels, Belgium

 

Prof. Dr. A. Axelsson

University of Lund, Lund, Sweden

 

Prof. Dr. K. Maeder

Martin Luther University. Halle-Wittenberg, Germany

 

Pr. Dr. D. Craig

UCL School of Pharmacy, London, UK

 

Prof. Dr. P. Kleinebudde

University of Duesseldorf, Duesseldorf, Germany

 

Pr. Dr. W. Jones

University of Cambridge, Cambridge, UK

 

Prof. Dr. T. Rades

University of Copenhagen, Copenhagen, Denmark

 

International

 

Dr. Y. Chen

University of Sydney, Australia

 

Prof. Dr. T. Pongjanyakul

Mahidol University, Bangkok, Thailand

 

Prof. Dr. N. Peppas

University of Texas at Austin, USA

 

Prof. Dr. J. McGinity and Prof. Dr. B. Williams III

University of Texas at Austin, USA

 

Collaborations industrielles 

 

  • Neurelec, R&D, Vallauris, France
  • ImaBiotech, R&D, Loos, France
  • Gattefossé, R&D, Lyon, France
  • FMC Biopolymer, R&D, Brussels, Belgium
  • BASF, R&D, Ludwigshafen, Germany
  • Merck, R&D, Hoddesdon, UK
  • Astra Zeneca, R&D, Lund, Sweden
  • Meggle, BG Excipients & Technology, Wasserburg, Germany
  • Bayer, R&D, Berlin, Germany